On the battlefields of the American Revolution, Matthew de Clermont meets Marcus MacNeil, a young surgeon from Massachusetts, during a moment of political awakening when it seems that the world is on the brink of a brighter future. When Matthew offers him a chance at immortality and a new life free from the restraints of his puritanical upbringing, Marcus seizes the opportunity to become a vampire. But his transformation is not an easy one and the ancient traditions and responsibilities of the de Clermont family clash with Marcus's deeply held beliefs in liberty, equality, and brotherhood.

Fast-forward to contemporary Paris, where Phoebe Taylor--the young employee at Sotheby's whom Marcus has fallen for--is about to embark on her own journey to immortality. Though the modernized version of the process at first seems uncomplicated, the couple discovers that the challenges facing a human who wishes to be a vampire are no less formidable than they were in the eighteenth century. The shadows that Marcus believed he'd escaped centuries ago may return to haunt them both--forever.